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Serum-derived carcinoembryonic antigen (CEA) activates fibroblasts to induce a local re-modeling of the extracellular matrix that favors the engraftment of CEA-expressing tumor cells.
Abdul-Wahid A, Cydzik M, Fischer NW, Prodeus A, Shively JE, Martel A, Alminawi S, Ghorab Z, Berinstein NL, Gariépy J. Abdul-Wahid A, et al. Among authors: fischer nw. Int J Cancer. 2018 Oct 15;143(8):1963-1977. doi: 10.1002/ijc.31586. Epub 2018 Aug 9. Int J Cancer. 2018. PMID: 29756328 Free PMC article.
TP53 Mutation Analysis in Gastric Cancer and Clinical Outcomes of Patients with Metastatic Disease Treated with Ramucirumab/Paclitaxel or Standard Chemotherapy.
Graziano F, Fischer NW, Bagaloni I, Di Bartolomeo M, Lonardi S, Vincenzi B, Perrone G, Fornaro L, Ongaro E, Aprile G, Bisonni R, Prisciandaro M, Malkin D, Gariépy J, Fassan M, Loupakis F, Sarti D, Del Prete M, Catalano V, Alessandroni P, Magnani M, Ruzzo A. Graziano F, et al. Among authors: fischer nw. Cancers (Basel). 2020 Jul 24;12(8):2049. doi: 10.3390/cancers12082049. Cancers (Basel). 2020. PMID: 32722340 Free PMC article.